| [1] Stefanacci R G. 默沙东诊疗手册大众版 [Z].
[2] Who. China country assessment report on ageing and health [Z].
[3] Zhu Y-F, Wu A-G, Chen M-Y, et al. Plant-based strategies against aging: Focus on bioactive compounds from medicine-food homology plants [J]. Phytomedicine, 2025, 145: 157052.
[4] 国家药典委员会。中华人民共和国药典:一部 [M]. 北京:中国医药科技出版社,2020.
[5] 中华人民共和国卫生部。卫生部关于进一步规范保健食品原料管理的通知 [EB/OL]. https://www.nhc.gov.cn/sps/c100088/200203/33c67ea059284ceea9e45ce61271cd12.shtml. 2002-02-28.
[6] 神农本草经 [M]. 杨鹏举,校注,顾观光,辑。北京:学苑出版社,2007.
[7] Xuan T, Liu Y, Liu R, et al. Advances in Extraction, Purification, and Analysis Techniques of the Main Components of Kudzu Root: A Comprehensive Review [J]. Molecules, 2023, 28 (18).
[8] 梅峥嵘,谭湘萍,黄汉辉,等。葛根素对阿尔茨海默病细胞模型 Aβ 蛋白的抑制作用 [J]. 中国现代应用药学,2015, 32 (01): 5-9.
[9] 阚晓月,余江南,徐希明。葛根多糖及其结构与活性关系的研究进展 [J]. 食品工业科技,2019, 40 (20): 356-362.
[10] 李思慧,刘雨诗,张雯晋,等。葛根中总黄酮含量测定方法比较研究 [J]. 中药与临床,2024, 15 (03): 1-5, 11.
[11] 杨琳,黄瑞珠,南奕阳,等。葛根异黄酮对 D - 半乳糖致亚急性衰老小鼠 T 细胞功能及端粒酶活性的影响 [J]. 中药新药与临床药理,2022, 33 (07): 889-892.
[12] 王爱梅,徐持华。葛根异黄酮对衰老模型大鼠学习记忆及海马 CA1 区长时程增强的影响 [J]. 中国老年学杂志,2012, 32 (13): 2799-2800.
[13] 石立鹏。葛根素调控心肌细胞衰老和肠道微生物群改善心肌纤维化的机制研究 [D]. 重庆:重庆医科大学,2024.
[14] Hou Q, Huang J, Zhao L, et al. Dietary genistein increases microbiota-derived short chain fatty acid levels, modulates homeostasis of the aging gut, and extends healthspan and lifespan [J]. Pharmacol Res, 2023, 188: 106676.
[15] 王秋丹,赵凯迪,林长青。葛根多糖抗氧化性及其降血糖作用研究 [J]. 食品工业科技,2022, 43 (05): 381-388.
[16] Shao X-Y, He T, Lai Y-L, et al. Water-Soluble Polysaccharides Extracted from Pueraria lobata Delay Aging of Caenorhabditis elegans under Heat Stress [J]. Plant Foods Hum. Nutr, 2022, 77 (2): 220-225.
[17] Liu L, Liang J, He M, et al. Pueraria lobata-derived peptides hold promise as a novel antioxidant source by mitigating ethanol-induced oxidative stress in HepG2 cells through regulating the Keap1/Nrf2 pathway [J]. Food Chem, 2025, 490: 145014.
[18] 王苗。葛根蛋白的提取及抗氧化、抗疲劳活性研究 [D]. 长春:长春中医药大学,2021.
[19] Navarro C, Salazar J, Díaz M P, et al. Intrinsic and environmental basis of aging: A narrative review [J]. Heliyon, 2023, 9 (8): e18239.
[20] Kroemer G, Maier A B, CUERVO A M, et al. From geroscience to precision geromedicine: Understanding and managing aging [J]. Cell, 2025, 188 (8): 2043-2062.
[21] Oo J, Kim M, Kim J, et al. Effects of Cnidium officinale, Pueraria lobata Ohwi, and Leonurus japonicus Extract on Vascular Endothelial Dysfunctions in Ovariectomized Rats and Molecular Mechanisms [J]. Int. J. Mol. Sci, 2025, 26 (10): 4708.
[22] Fu C, Chen B, Jin X, et al. Puerarin protects endothelial progenitor cells from damage of angiotensin II via activation of ERK1/2-Nrf2 signaling pathway [J]. Mol Med Rep, 2018, 17 (3): 3877-3883.
[23] Kang A-W, Sun C, Li H-T, et al. Puerarin extends the lifespan of Drosophila melanogaster by activating autophagy [J]. Food & Function, 2023, 14 (4): 2149-2161.
[24] 周凡,高扬,胡艳平,等。葛根素调控 SIRT1-FOXO1 信号通路介导的自噬对类固醇诱导的成骨细胞凋亡的影响 [J/OL]. 中国骨质疏松杂志,1-11 [2025-10-21]. https://link.cnki.net/urlid/11. 3701. R. 20240920. 1616. 002.
[25] 丁秀丽,徐舜。葛根素介导自噬对环磷酰胺诱导卵巢早衰大鼠的作用研究 [J]. 浙江中西医结合杂志,2025, 35 (07): 608-614.
[26] 吴景东,王培,李东子。葛根及葛根素对自然衰老小鼠 mtDNA 片段缺失的实验研究 [J]. 辽宁中医杂志,2011, 38 (11): 2119-2120.
[27] Fang Y, Huang L, Li F, et al. Puerarin Ameliorates Premature Ovarian Failure by Activation of Mitochondrial Biogenesis, Dynamics, and Mitophagy Through Up-Regulation of SIRT1 [J]. Advanced Therapeutics, 2025, 8 (5).
[28] 裴凌鹏,常铮,金宗濂。葛根黄酮改善老龄小鼠抗氧化功能的研究 [J]. 营养学报,2004 (06): 505-506.
[29] Huang Z, Liu Y, Huang X. Formononetin may protect aged hearts from ischemia/reperfusion damage by enhancing autophagic degradation [J]. Mol Med Rep, 2018, 18 (6): 4821-4830.
[30] Deng Y, Lei T, Li H, et al. ERK5/KLF2 activation is involved in the reducing effects of puerarin on monocyte adhesion to endothelial cells and atherosclerotic lesion in apolipoprotein E-deficient mice [J]. Biochim Biophys Acta Mol Basis Dis, 2018, 1864 (8): 2590-2599.
[31] 王丹姝,燕柳艳,孙姝婵,等。葛根素通过 TLR4/Myd88/NF-κB 抑制 NLRP3 炎症小体抗大鼠心肌缺血再灌注损伤 [J]. 药学学报,2021, 56 (05): 1343-1351.
[32] Wu X D, Wang C, Zhang Z Y, et al. Puerarin attenuates cerebral damage by improving cerebral microcirculation in spontaneously hypertensive rats [J]. Evid Based Complement Alternat Med, 2014, 2014: 408501.
[33] 高俊凤,刘曼曼,郭召平,等。葛根素通过 Fetuin B-AMPK/ACC 信号通路减轻 2 型糖尿病小鼠肝脏胰岛素抵抗 [J]. 南方医科大学学报,2021, 41 (06): 839-846.
[34] Song X, Dong H, Zang Z, et al. Kudzu Resistant Starch: An Effective Regulator of Type 2 Diabetes Mellitus [J]. Oxid Med Cell Longev, 2021, 2021: 4448048.
[35] Hong X P, Chen T, Yin N N, et al. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain [J]. J Alzheimers Dis, 2016, 51 (2): 605-617.
[36] Zhang Y, Chen Y, Shan Y, et al. Effects of puerarin on cholinergic enzymes in the brain of ovariectomized guinea pigs [J]. Int J Neurosci, 2013, 123 (11): 783-791.
[37] Zhu G, Wang X, Chen Y, et al. Puerarin protects dopaminergic neurons against 6-hydroxydopamine neurotoxicity via inhibiting apoptosis and upregulating glial cell line-derived neurotrophic factor in a rat model of Parkinson’s disease [J]. Planta Med, 2010, 76 (16): 1820-1826.
[38] Park K H, Gu D R, Jin S H, et al. Pueraria lobate Inhibits RANKL – Mediated Osteoclastogenesis Via Downregulation of CREB/PGC1β/c-Fos/NFATc1 Signaling [J]. Am J Chin Med, 2017, 45 (8): 1725-1744.
[39] Li B, Liu M, Wang Y, et al. Puerarin improves the bone micro-environment to inhibit OVX-induced osteoporosis via modulating SCFAs released by the gut microbiota and repairing intestinal mucosal integrity [ J ]. Biomed Pharmacother, 2020, 132: 110923. |